产品货号：
Z21839
中文名称：
NPAS3抗体
英文名称：
Anti-NPAS3 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-NPAS3 Antibody |
| 指标别名 | MOP6,PASD6,bHLHe12,BHLHE12,MOP6,Neuronal PAS domain-containing protein 3,Basic-helix-loop-helix-PAS protein MOP6,Neuronal PAS3 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | NPAS3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | NPAS3 antibody was raised against a 28 amino acid synthetic peptide from near the amino terminus of human NPAS3.The immunogen is located within amino acids 40 - 90 of NPAS3. |
| 计算分子量 | 101kDa |
| 成分 | NPAS3 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | NPAS3 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor and is broadly expressed in the developing neuroepithelium and has recently found to be disrupted by genetic translocation in a family affected with schizophrenia.It was recently shown to be involved in the regulation of FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1 and in turn neurogenesis emanating from this region.NPAS3-null mice were growth-retarded and displayed brain defects that included reduced size of the anterior hippocampus,hypoplasia of the corpus callosum,and enlargement of the ventricles,as well as several behavioral abnormalities.Furthermore,these NPAS3-null mice also exhibited disruptions in several neurosignaling pathways involving glutamate,dopamine,and serotonin.These results demonstrate the essential role played by NPAS3 during structural and functional brain development.At least three isoforms of NPAS3 are known to exist. |
| Uniprot ID | Q8IXF0 |
| 基因名全称 | Neuronal PAS domain protein 3 |
| 蛋白名全称 | Neuronal PAS domain protein 3 |
| 推荐稀释比 | NPAS3 antibody can be used for detection of NPAS3 by Western blot at 0.5 ～ 2μg/mL.Antibody can also be used for immunohistochemistry starting at 5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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